γ-氨基丁酸转运体中的通道行为。
Channel behavior in a gamma-aminobutyrate transporter.
作者信息
Cammack J N, Schwartz E A
机构信息
Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):723-7. doi: 10.1073/pnas.93.2.723.
Abstract
Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian cell line was observed in cell-attached and excised membrane patches. When GABA was absent, a fraction of the transporters produced cation-permeable channels. When GABA plus Na+ was on either side of the membrane, the majority of transporters produced a high-frequency current noise attributed to the movement of ions in an occluded pore.
摘要
在细胞贴附式和切除式膜片上观察到由稳定转染到哺乳动物细胞系中的γ-氨基丁酸（GABA）转运体产生的电流。当不存在GABA时，一部分转运体产生阳离子通透通道。当膜两侧都存在GABA加Na+时，大多数转运体产生高频电流噪声，这归因于离子在封闭孔中的移动。
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