终末期肾衰竭患者血液透析期间血浆醛固酮的控制

Control of plasma aldosterone during hemodialysis in patients with terminal renal failure.

作者信息

Vetter W, Záruba K, Armbruster H, Beckerhoff R, Nussberger J, Furrer J, Fontana A, Siegenthaler W

出版信息

Nephron. 1977;18(2):114-23. doi: 10.1159/000180785.

Abstract

The control of plasma aldosterone during hemodialysis was investigated in 31 patients with terminal renal failure. While before hemodialysis renin predominantly influenced aldosterone, this effect dissipated during hemodialysis. In addition, no relationship was observed between changes in aldosterone and those in sodium, potassium and plasma cortisol. In a group of 10 patients isokalemic and isonatremic hemodialysis failed to document an effect sodium or potassium on hemodialysis induced changes in aldosterone. Our data suggest that none of the four factors - renin, ACTH, sodium and potassium - had constantly caused the observed changes in aldosterone during hemodialysis.

摘要

对31例终末期肾衰竭患者进行了血液透析期间血浆醛固酮控制情况的研究。血液透析前肾素对醛固酮起主要影响作用，但在血液透析期间这种作用消失。此外，未观察到醛固酮变化与钠、钾及血浆皮质醇变化之间存在关联。在一组10例血钾和血钠正常的患者中，等钾等钠血液透析未能证明钠或钾对血液透析引起的醛固酮变化有影响。我们的数据表明，肾素、促肾上腺皮质激素、钠和钾这四个因素在血液透析期间均未持续导致所观察到的醛固酮变化。