Sciarra F, Sparano F, Giaquinto G, Odoardi A, Mercuri M A, Concolino G
Horm Res. 1977;8(3):129-38. doi: 10.1159/000178791.
The present investigation was carried out on 17 male patients, 2 of whom nephrectomized, affected by terminal renal failure on regular 4 h dialysis three times a week. Plasma prolactin (PRL), aldosterone (PA) and renin activity (PRA) were determined by radioimmunoassay before, and after the 1st, 2nd and 3rd h of hemodialysis. High levels of PRL were found in 9 nonnephrectomized patients; during the 1st and 2nd h of dialysis means values of PRL showed a slight tendency to increase, whilst during the 3rd h values decreased to predialysis concentrations. In one case a fall in PRL levels immediately after nephrectomy was observed but in another patient who came to our attention after surgery, PRL was significantly increased with values higher than those usually found in nonnephrectomized patients. PRA was elevated in 10 patients and showed no significant modifications during hemodialysis. PAC was high in 8 patients and decreased significantly during hemodialysis. A drop in sodium and potassium levels and a decrease in body weight during dialysis were also observed. These results suggest that in uremia the high levels of PRL are not consequent to hydroelectrolyte disorders or to a condition of hyperaldosteronism, since these parameters present a different pattern during hemodialysis.
本研究对17例男性患者进行，其中2例接受了肾切除术，这些患者患有终末期肾衰竭，每周定期进行3次4小时的透析。在血液透析第1、2和3小时之前及之后，通过放射免疫测定法测定血浆催乳素（PRL）、醛固酮（PA）和肾素活性（PRA）。在9例未接受肾切除术的患者中发现PRL水平较高；在透析的第1和第2小时，PRL的均值有轻微上升趋势，而在第3小时，其值降至透析前浓度。在1例患者中，肾切除术后立即观察到PRL水平下降，但在另1例术后引起我们注意的患者中，PRL显著升高，其值高于未接受肾切除术患者通常所见的值。10例患者的PRA升高，且在血液透析期间无显著变化。8例患者的PAC较高，且在血液透析期间显著下降。透析期间还观察到钠和钾水平下降以及体重减轻。这些结果表明，在尿毒症中，PRL水平升高并非由水电解质紊乱或醛固酮增多症所致，因为这些参数在血液透析期间呈现出不同的模式。
