Takeda A, Sawashita J, Okada S
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Brain Res. 1995 Oct 9;695(1):53-8. doi: 10.1016/0006-8993(95)00916-e.
The brains of rats injected intravenously with 65ZnCl2 or 54MnCl2 were subjected to high-resolution autoradiography. The distribution of 65Zn and 54Mn in each brain region gradually decreased from 6 days to 42 days for 65Zn and from 15 days to 60 days for 54Mn after the injection. The biological half-lives of Zn in each region studied were in the range of 16-43 days; the longest was observed in the amygdaloid nuclei. The regions where the long biological half-life was observed were consistent with the ones with the high density of Zn-containing neuron terminals reported previously. The biological half-lives of Mn in each region were 51-74 days; the longest were those in the hypothalamic nuclei and thalamus.
给大鼠静脉注射65ZnCl2或54MnCl2后，对其大脑进行高分辨率放射自显影。注射后，65Zn在各脑区的分布从6天到42天逐渐减少，54Mn在各脑区的分布从15天到60天逐渐减少。所研究的每个区域中锌的生物半衰期在16 - 43天范围内；在杏仁核中观察到最长的半衰期。观察到长生物半衰期的区域与先前报道的含锌神经元终末高密度区域一致。每个区域中锰的生物半衰期为51 - 74天；最长的是在下丘脑核和丘脑中。
