Takeda A, Sawashita J, Okada S
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan.
Neurosci Lett. 1998 Feb 6;242(1):45-8. doi: 10.1016/s0304-3940(98)00006-8.
54Mn distribution in the brain and peripheral tissues was studied with the course of time after intravenous injection of 54MnCl2 to see manganese (Mn) transport from the peripheral tissues, i.e. the liver, to the brain. One hour after injection, 54Mn concentrations in the brain were 0.15-0.25% dose/g, and 54Mn was largely concentrated in the choroid plexus. One day after injection, 54Mn in the choroid plexus decreased remarkably. 54Mn in other brain regions increased gradually after then, and reached 0.30-0.40% dose/g 6 days after injection. This increase of 54Mn was due to the redistribution from the peripheral tissues such as liver and pancreas, in which 54Mn was maintained at high levels (2.0-4.0% dose/g). The increment of 54Mn 1 h to 6 days after injection was the largest in the hippocampus, but not in the striatum. These results suggest that the delivery of Mn from the liver to the brain is not involved in preferential Mn accumulation in the basal nuclei under physiological condition. This delivery may be important for brain function.
静脉注射54MnCl2后，随着时间推移研究了54Mn在脑和外周组织中的分布，以观察锰（Mn）从外周组织（即肝脏）向脑的转运情况。注射后1小时，脑中54Mn浓度为0.15 - 0.25%剂量/克，且54Mn大量集中在脉络丛。注射后1天，脉络丛中的54Mn显著减少。此后，其他脑区的54Mn逐渐增加，注射后6天达到0.30 - 0.40%剂量/克。54Mn的这种增加是由于从肝脏和胰腺等外周组织的重新分布，其中54Mn维持在高水平（2.0 - 4.0%剂量/克）。注射后1小时到6天，54Mn的增加在海马体中最大，但在纹状体中并非如此。这些结果表明，在生理条件下，从肝脏到脑的锰输送与基底核中锰的优先积累无关。这种输送可能对脑功能很重要。
