Takeda A, Ishiwatari S, Okada S
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
J Neurosci Res. 1999 Apr 1;56(1):93-8. doi: 10.1002/(SICI)1097-4547(19990401)56:1<93::AID-JNR12>3.0.CO;2-P.
Manganese (Mn) is an essential metal and plays an important role in the brain. To evaluate Mn uptake into the brain during development and aging, 54Mn concentrations in the brain of rats aged from 5 days to 95 weeks were measured after injection of 54MnCl2. 54Mn concentration in the brain of 5-day-old rats was the highest of all age groups tested. The liver and blood of 5-day-old rats also showed the highest 54Mn concentrations among the age groups. These results suggest that Mn is required in a high amount during infancy and that a sufficient Mn supply is critical for normal brain development. The high uptake of Mn into the brain of neonatal rats may be due to high levels of Mn in the blood, which may be supplied from the liver. In the 5-day-old brain, 54Mn was relatively concentrated in the hippocampal CA3 and dentate gyrus and the pons. In the aging brain, 54Mn was relatively concentrated in the inferior colliculi, olivary nuclei and red nuclei.
锰（Mn）是一种必需金属，在大脑中发挥着重要作用。为了评估发育和衰老过程中大脑对锰的摄取情况，在注射54MnCl2后，测量了5日龄至95周龄大鼠大脑中的54Mn浓度。5日龄大鼠大脑中的54Mn浓度在所有测试年龄组中最高。5日龄大鼠的肝脏和血液中的54Mn浓度在各年龄组中也最高。这些结果表明，婴儿期需要大量的锰，充足的锰供应对正常大脑发育至关重要。新生大鼠大脑对锰的高摄取可能是由于血液中锰水平较高，而血液中的锰可能来自肝脏。在5日龄的大脑中，54Mn相对集中在海马CA3区、齿状回和脑桥。在衰老的大脑中，54Mn相对集中在下丘、橄榄核和红核。
