Takeda A, Akiyama T, Sawashita J, Okada S
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Brain Res. 1994 Mar 21;640(1-2):341-4. doi: 10.1016/0006-8993(94)91891-0.
The brains of rats injected intravenously with 65ZnCl2 or 54MnCl2 were subjected to high resolution autoradiography. 65Zn and 54Mn were largely concentrated in choroid plexus 1 h after injection and then gradually decreased, with increases in other brain regions, suggesting that both metals were taken up gradually into brain mainly via cerebrospinal fluid in the choroid plexus. By 3 days after injection, relatively high level of 65Zn was seen in the dentate gyrus and CA3 region of the hippocampus and in the cerebral cortex. The level of 54Mn was also high in the former, while relatively low in the latter.
给大鼠静脉注射65ZnCl2或54MnCl2后，对其大脑进行高分辨率放射自显影。注射后1小时，65Zn和54Mn主要集中在脉络丛，随后逐渐减少，而其他脑区的含量增加，这表明这两种金属主要通过脉络丛中的脑脊液逐渐进入大脑。注射后3天，在海马齿状回和CA3区以及大脑皮层中观察到相对较高水平的65Zn。前者中54Mn的水平也较高，而后者中相对较低。
