Szabo A, Stolz L, Granzow R
Pharmacia Biosensor, Piscataway, USA.
Curr Opin Struct Biol. 1995 Oct;5(5):699-705. doi: 10.1016/0959-440x(95)80064-6.
Since the advent of surface plasmon resonance (SPR)-based interaction analysis techniques in 1990 the field has grown rapidly. So far, more than 220 publications and hundreds of laboratories have reported useful applications for this label-free real-time binding approach. Milestones passed during the past year include the direct detection of low molecular mass (200 Da) binding events and applications in several new fields as disparate as chaperonins, cellular adhesion, molecular biology, transcription and small-molecule screening.
自1990年基于表面等离子体共振（SPR）的相互作用分析技术问世以来，该领域发展迅速。迄今为止，已有220多篇出版物和数百个实验室报道了这种无标记实时结合方法的有用应用。过去一年取得的里程碑式成果包括对低分子量（200道尔顿）结合事件的直接检测，以及在伴侣蛋白、细胞粘附、分子生物学、转录和小分子筛选等多个新领域的应用。
