Turner A S, Norrdin R W, Gaarde S, Connally H E, Thrall M A
Department of Clinical Sciences, Colorado State University, Ft. Collins 80523, USA.
Calcif Tissue Int. 1995 Sep;57(3):191-5. doi: 10.1007/BF00310257.
Dual-energy X-ray absorptiometry (DXA) was used to determine the in vivo bone mineral density (BMD) and bone mineral content (BMC) of lumbar vertebrae in six cats affected with the inherited lysosomal storage disease mucopolysaccharidosis VI (MPS VI). DXA was also performed on MPS cats that had a bone marrow transplant (BMT) and total body irradiation (TBI) (MPS + BMT; n = 7), normal cats that had a bone marrow transplant, and TBI (control + BMT; n = 8) and normal cats (control; n = 14). Following euthanasia, one of the lumbar vertebrae that had been scanned (L5) was harvested and bone volume (BV/TV%) was determined by histomorphometry. The in vivo BMD and BMD measurements were compared with the BV/TV%. There was a greater BMD and BMC in the MPS + BMT cats compared with the MPS cats but the difference was not statistically significant. However, there was a greater BV/TV% in the MPS + BMT cats compared with the MPS cats and the difference was significant (P = 0.0152). Correlation between the noninvasive in vivo DXA measurements of BMD and BMC and the BV/TV% was significant (r2 = 0.767, P < 0.0001; r2 = 0.504, P < 0.0001). Noninvasive in vivo DXA was a rapid and precise method for measuring the lumbar BMD and BMC in cats and it correlated well with histomorphometric determination of bone mass. Further, the response of inherited storage diseases such as MPS VI to therapy, such as BMT, could be monitored in a longitudinal fashion using DXA.
采用双能X线吸收法（DXA）测定了6只患有遗传性溶酶体贮积病黏多糖贮积症VI型（MPS VI）的猫的腰椎活体骨密度（BMD）和骨矿物质含量（BMC）。对接受了骨髓移植（BMT）和全身照射（TBI）的MPS猫（MPS + BMT；n = 7）、接受了骨髓移植和TBI的正常猫（对照 + BMT；n = 8）以及正常猫（对照；n = 14）也进行了DXA检测。安乐死后，采集其中一个已扫描的腰椎（L5），通过组织形态计量学测定骨体积（BV/TV%）。将活体BMD和BMD测量值与BV/TV%进行比较。与MPS猫相比，MPS + BMT猫的BMD和BMC更高，但差异无统计学意义。然而，与MPS猫相比，MPS + BMT猫的BV/TV%更高，差异具有统计学意义（P = 0.0152）。BMD和BMC的非侵入性活体DXA测量值与BV/TV%之间的相关性具有统计学意义（r2 = 0.767，P < 0.0001；r2 = 0.504，P < 0.0001）。非侵入性活体DXA是一种快速、精确的方法，可用于测量猫的腰椎BMD和BMC，并且与骨量的组织形态计量学测定具有良好的相关性。此外，使用DXA可以纵向监测诸如MPS VI等遗传性贮积病对BMT等治疗的反应。
