衰老过程中的CD8 + T细胞亚群

CD8+ T cell subsets in aging.

作者信息

Ruiz M, Esparza B, Pérez C, Barranquero M, Sabino E, Merino F

机构信息

School of Medicine, Universidad del País Vasco, Leioa, Vizcaya, Spain.

出版信息

Immunol Invest. 1995 Nov;24(6):891-5. doi: 10.3109/08820139509060715.

DOI:10.3109/08820139509060715

PMID:8575835

Abstract

Infections are major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes -which play a crucial role in host defence against viral infections-. are divided in subsets based upon the expression of several cell and activation markers. Since in senescence changes in peripheral blood CD8+ T lymphocyte compartment have been described, studies were performed to determine whether in aging there are variations in the peripheral blood CD8+CD38+, CD8+CD57+, CD8+HLA-DR+, CD8+CD45RA+ and CD8+CD45RO+ cell subset. A decrease in the CD8+CD45RA+ lymphocytes was observed, indicating that variations in the CD8+ compartment can take place with ageing.

摘要

感染是老年人患病和死亡的主要原因。外周血CD8 + T淋巴细胞——在宿主抵御病毒感染中起关键作用——根据几种细胞和激活标志物的表达分为不同亚群。由于已描述了衰老过程中外周血CD8 + T淋巴细胞区室的变化，因此开展了研究以确定在衰老过程中外周血CD8 + CD38 +、CD8 + CD57 +、CD8 + HLA - DR +、CD8 + CD45RA +和CD8 + CD45RO +细胞亚群是否存在变化。观察到CD8 + CD45RA +淋巴细胞减少，表明CD8 +区室的变化可能随衰老而发生。