Jackson D A, Cook P R
CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
Int Rev Cytol. 1995;162A:125-49. doi: 10.1016/s0074-7696(08)61230-9.
Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.
大多数转录和复制模型都涉及沿着模板移动的聚合酶。我们在此回顾一些实验，这些实验表明了另一种情况，即聚合作用发生在模板滑过固定于真核细胞核大型结构上的聚合酶时，该大型结构是附着于核骨架的“工厂”。这意味着高阶结构决定了DNA复制或转录的方式和时间。
