患有关节炎和未患关节炎的麻风病患者的免疫学参数。
Immunological parameters in leprosy patients with and without arthritis.
作者信息
Pal S, Singh S B, Bhattacharya S K
机构信息
Department of Medicine, Banaras Hindu University, Varanasi.
出版信息
J Indian Med Assoc. 1995 Jul;93(7):266-7.
Twelve patients of leprosy with arthritis and 161 patients without arthritis were studied for immunological parameters like immunoglobulins (IgG, IgM, IgA), C-reactive proteins and rheumatoid factor. There was increase in the levels of IgG, IgA value in leprosy patients with and without arthritis compared to healthy control. IgM level was decreased in both the groups compared to control, but significant decrease was observed (p < .01) in patients with arthritis. C-reactive protein was significantly positive in leprosy with arthritis group (p < .01) and positive in 12 cases of leprosy without arthritis group compared to negative control group. Rheumatoid factor was present in leprosy with arthritis (16.6%) compared to both the control group and leprosy without arthritis group. This study concluded the presence of arthritis in leprosy patients as a definite entity which showed changes in immunological parameters.
对12例患有关节炎的麻风病患者和161例无关节炎的患者进行了免疫球蛋白（IgG、IgM、IgA）、C反应蛋白和类风湿因子等免疫学参数研究。与健康对照组相比，患有关节炎和无关节炎的麻风病患者的IgG、IgA水平均有所升高。与对照组相比，两组的IgM水平均降低，但患有关节炎的患者中观察到显著降低（p < 0.01）。C反应蛋白在患有关节炎的麻风病组中显著呈阳性（p < 0.01），与阴性对照组相比，在12例无关节炎的麻风病组中呈阳性。与对照组和无关节炎的麻风病组相比，患有关节炎的麻风病患者中类风湿因子的存在率为16.6%。本研究得出结论，麻风病患者中的关节炎是一种明确的疾病实体，其免疫学参数发生了变化。
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