Koseki N, Araie M, Suzuki Y, Yamagami J
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Jpn J Ophthalmol. 1995;39(3):274-83.
To compare in more detail the central visual field damage in normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) eyes, a pointwise inner-group comparison of the data obtained with the Humphrey 10-2 was carried out in 68 NTG cases with maximum intraocular pressure (IOP) of < or = 21 mmHg and 62 HTG cases with maximum IOP of > or = 25 mmHg. All eyes had the usual field defects, with a mean deviation of > or = -15 dB (MD, STATPAC). Age, refraction and MD were matched between the two groups. Total deviation (TD, STATPAC), the difference between the measured threshold and the age-corrected normal reference at each test point of the 10-2 program, was used for pointwise inter-group comparisons. The data were analyzed with Wilcoxon rank-sum test and logistic discriminant analysis. The latter method was also applied to the data of the 30-2 program to confirm the results obtained with the 10-2 program. The comparisons using the different methods and programs gave consistent results. For a given amount of overall visual field damage in the two types of glaucoma, a superior arcuate area extending down to the horizontal meridian just nasal to the fixation point was significantly more depressed and an area inferior to the horizontal meridian and inferior temporal to the fixation point significantly less depressed in NTG eyes. HTG eyes were significantly more diffusely damaged in the central 10-degree visual field. NTG and HTG may have unique patterns of central visual field damage. These differences may implications in following NTG patients and studying the pathogenesis of this glaucoma.
为了更详细地比较正常眼压性青光眼（NTG）和高眼压性青光眼（HTG）患者的中心视野损害情况，我们对68例最大眼压（IOP）≤21 mmHg的NTG患者和62例最大眼压≥25 mmHg的HTG患者进行了Humphrey 10-2视野检查数据的组内逐点比较。所有患者均存在常见的视野缺损，平均偏差≥ -15 dB（MD，STATPAC）。两组患者在年龄、屈光状态和MD方面相匹配。总偏差（TD，STATPAC），即10-2程序各测试点测量阈值与年龄校正后的正常参考值之间的差值，用于组间逐点比较。数据采用Wilcoxon秩和检验和逻辑判别分析进行分析。后一种方法也应用于30-2程序的数据，以确认10-2程序获得的结果。使用不同方法和程序进行的比较得出了一致的结果。对于两种类型青光眼相同程度的总体视野损害，NTG患者中，延伸至注视点鼻侧水平子午线下方的上半弓形区域明显更凹陷，水平子午线下方及注视点颞下区域明显凹陷程度较小。HTG患者在中央10度视野中损害更广泛。NTG和HTG可能具有独特的中心视野损害模式。这些差异可能对NTG患者的随访及该型青光眼发病机制的研究具有重要意义。
