Araie M, Arai M, Koseki N, Suzuki Y
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Jpn J Ophthalmol. 1995;39(1):60-4.
It is known that the prevalence of normal tension glaucoma (NTG) or primary open angle glaucoma (POAG) is higher in the myopic population and that the prevalence of myopia and NTG is higher in Japan than in western countries. To evaluate the influence of myopic refractive error in the central 10 degrees of the visual field in NTG eyes, the data obtained from NTG eyes with the Humphrey Visual Field Analyzer were analyzed in comparison with data from POAG eyes. One hundred and twenty eyes of 86 NTG patients and 197 eyes of 138 POAG patients whose ages were 65 years or younger were included in this study. All of them had clear ocular media, refractive power less than +1.0 diopter and no myopic degeneration in the fundus. Multiple linear regression analysis was performed with the dependent variable of the deviation of the measured threshold value from the normal reference value (TD; STATPAC 2), and independent variables of myopic refractive power and the mean deviation (MD; STATPAC 2) as an index of the disease stage at each test point of the Humphrey 10-2 program and at the most central 12 test points of the 30-2 program. Myopic power was found to have a significant positive correlation with the depression in the lower cecocentral area in both NTG and POAG eyes, while only in NTG eyes it had a significant negative correlation with the depression in the upper arcuate area extending just nasal to the fixation point.
已知正常眼压性青光眼（NTG）或原发性开角型青光眼（POAG）在近视人群中的患病率较高，且日本近视和NTG的患病率高于西方国家。为了评估近视屈光不正对NTG患者中央10度视野的影响，将使用Humphrey视野分析仪从NTG患者眼中获得的数据与POAG患者的数据进行比较分析。本研究纳入了86例NTG患者的120只眼和138例POAG患者的197只眼，这些患者年龄均在65岁及以下。所有患者的眼内介质清晰，屈光力小于+1.0屈光度，眼底无近视性变性。以测量阈值与正常参考值的偏差（TD；STATPAC 2）为因变量，以近视屈光力和平均偏差（MD；STATPAC 2）为自变量进行多元线性回归分析，MD作为Humphrey 10-2程序各测试点以及30-2程序最中央12个测试点疾病阶段的指标。结果发现，近视度数在NTG和POAG眼中均与下方视盘中心周围区域的缺损呈显著正相关，而仅在NTG眼中，近视度数与刚好位于注视点鼻侧的上方弓形区域的缺损呈显著负相关。
