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[长期运动不足人群中前列腺素含量及脂质代谢若干指标的动态变化]

[Dynamics of prostaglandin contents and several indicators of lipid metabolism in man exposed to prolonged hypokinesis].

作者信息

Naĭdina V P, Larina I P, Zharkovskaia E E, Sukhanov Iu V

出版信息

Kosm Biol Aviakosm Med. 1991 Sep-Oct;25(5):33-6.

PMID:8577137
Abstract

Nine healthy test subjects divided into Group A and Group B were bed rested (with the head down at -5 degrees) for 370 days. Group A subjects exercised from the beginning of the study while Group B subjects began exercising only 120 days after. During the study prostaglandins PGE and PGF2 alpha in serum and fatty acids in serum and erythrocyte membranes were measured. The lipid concentration in erythrocyte membranes decreased during the study and returned to the norm at a final stage and after the study. However, changes in higher fatty acids and a dramatic decline of prostaglandin give evidence for serious alterations of lipid metabolism at the cellular level.

摘要

九名健康受试者被分为A组和B组,进行了370天的卧床休息(头部向下倾斜5度)。A组受试者从研究开始就进行锻炼,而B组受试者仅在120天后才开始锻炼。在研究期间,测量了血清中的前列腺素PGE和PGF2α以及血清和红细胞膜中的脂肪酸。研究期间红细胞膜中的脂质浓度降低,并在研究结束时和研究后恢复到正常水平。然而,高级脂肪酸的变化和前列腺素的急剧下降表明细胞水平的脂质代谢发生了严重改变。

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