Nekrasova A A, Zharova E A, Sokolova R I
Biull Eksp Biol Med. 1977 Apr;83(4):399-400.
A direct relationship between the level of the kallikrein activity in the urine, and diuresis, natriuresis and the capacity of the kidneys to concentrate the urine in healthy rats was revealed. Low doses of indometacin (2 mg/kg, for 5 days) increased the kallikrein activity in the urine four-fold, with a simultaneous rise of diuresis; high doses (5 mg/kg, for 5 days) cut the kallikrein activity in the urine by half and decreased natriuresis three-fold. At the same time there was also a decreased capacity to concentrate the urine. Thus, indometacin changed not only the prostaglandine synthesis, but also that of kallikrein, this influencing the functional state of the kidney.
在健康大鼠中，尿液中激肽释放酶活性水平与利尿、利钠以及肾脏浓缩尿液的能力之间存在直接关系。低剂量消炎痛（2毫克/千克，持续5天）使尿液中激肽释放酶活性增加四倍，同时利尿增加；高剂量（5毫克/千克，持续5天）使尿液中激肽释放酶活性减半，利钠减少三倍。与此同时，肾脏浓缩尿液的能力也降低。因此，消炎痛不仅改变了前列腺素的合成，还改变了激肽释放酶的合成，从而影响肾脏的功能状态。
