Behrbohm H, Kaschke O, Sydow K
Krankenhaus Berlin-Weissensee, HNO-Klinik.
Laryngorhinootologie. 1995 Dec;74(12):733-7. doi: 10.1055/s-2007-997835.
To date, there has not been sufficient experimental evidence to demonstrate the pharmacological effect of secretolytic and mucolytic drugs.
Scintigraphic studies to detect the mucociliary clearance in the maxillary sinus before and after application of the secretolytic drug Gelomyrtol forte were performed on four healthy persons and one patient after sinus surgery. The most important parameter was the mucociliary transport velocity of the "region of interest-maxillary sinus" and the increase of radioactivity accumulated in a tampon placed in the middle meatus of the nose. Measurements were done with a gamma-camera, 99 m Technetium-sulphurcolloid was used as the radiopharmacentical. A dose of 1 MBq in 0.2 ml NaCl-solution was injected into the maxillary sinus.
The results show a clear increase of mucociliary transport velocity in the maxillary sinus after intake of secretolytics in connection with an increase of radioactivity in the tampon.
The results can be explained by the secretolytic and secretomotoric effects of the investigated drug.
The study reveals that ethereal oils have secretolytic effects and also have a pharmacological effect on the mucociliary apparatus.
迄今为止，尚无足够的实验证据来证明促分泌和溶解黏液药物的药理作用。
对4名健康人及1名鼻窦手术后患者进行了闪烁扫描研究，以检测应用促分泌药物强力稀化粘素前后上颌窦的黏液纤毛清除功能。最重要的参数是“感兴趣区域-上颌窦”的黏液纤毛传输速度以及置于鼻中道的棉塞中放射性物质的积聚增加情况。使用γ相机进行测量，99m锝-硫胶体用作放射性药物。将0.2ml氯化钠溶液中1MBq的剂量注入上颌窦。
结果显示，摄入促分泌药物后，上颌窦的黏液纤毛传输速度明显增加，同时棉塞中的放射性也增加。
研究结果可以通过所研究药物的促分泌和促分泌运动作用来解释。
该研究表明，挥发油具有促分泌作用，并且对黏液纤毛装置也有药理作用。
