Jerome C P, Lees C J, Weaver D S
Department of Comparative Medicine, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1040, USA.
Bone. 1995 Oct;17(4 Suppl):403S-408S. doi: 10.1016/8756-3282(95)00318-8.
Spinal osteopenia that is due in part to failure to gain bone has previously been reported in ovariectomized nonhuman primates. In these studies, development of osteopenia over one year was followed by dual-energy x-ray absorptiometry in both domestically-reared and feral ovariectomized (OVX) and sham-ovariectomized (SHAM) cynomolgus monkeys. To promote development of absolute osteopenia, the domestically-reared animals were all older than nine years and were fed a diet containing 0.14% calcium for most of the experimental period. Both SHAM and OVX feral animals fed 0.6% calcium gained bone mass, with significantly lower rates of gain in SHAM monkeys. OVX domestically-reared monkeys lost bone during one year, while SHAM domestically-reared animals showed no significant change from baseline. Thus, relative osteopenia developed in both experiments, but only the domestically-reared animals developed absolute osteopenia. Nonhuman primates are the only animal model shown to develop absolute osteopenia after ovariectomy. These data suggest that absolute osteopenia develops after ovariectomy in monkeys with stable pre-ovariectomy bone mass which are fed a level of calcium comparable to that consumed by American women.
先前已有报道称，卵巢切除的非人灵长类动物存在部分因未能增加骨量而导致的脊柱骨质减少。在这些研究中，通过双能X线吸收法跟踪了圈养和野生的卵巢切除（OVX）及假卵巢切除（SHAM）食蟹猴在一年时间里骨质减少的发展情况。为了促进绝对骨质减少的发展，圈养动物均超过9岁，且在实验的大部分时间里喂食含钙量为0.14%的饮食。喂食0.6%钙的SHAM和OVX野生猴都增加了骨量，SHAM猴的骨量增加速率显著较低。圈养的OVX猴在一年中骨质流失，而圈养的SHAM动物与基线相比无显著变化。因此，两个实验中均出现了相对骨质减少，但只有圈养动物出现了绝对骨质减少。非人灵长类动物是唯一一种在卵巢切除后会出现绝对骨质减少的动物模型。这些数据表明，在卵巢切除前骨量稳定、喂食与美国女性摄入水平相当的钙量的猴子中，卵巢切除后会出现绝对骨质减少。
