Manton D J, Lowry M, Blackband S J, Horsman A
YCRC Centre for Magnetic Resonance Investigations, Department of Medical Physics, University of Hull, UK.
NMR Biomed. 1995 May;8(3):104-12. doi: 10.1002/nbm.1940080305.
Quantitative proton spectroscopic studies were performed on 39 volunteers and 16 patients with intracranial tumours. Estimates of T2 were obtained in white matter, grey matter, cerebellum, astrocytomas and meningiomas; T1 was determined in white matter only. White matter values of T2 for trimethylamines, creatine and N-acetyl aspartate (NAA) were 309 +/- 84, 195 +/- 41 and 369 +/- 124 ms, respectively (mean +/- SD, n = 20). Metabolite concentrations in white matter were 2.0 +/- 0.4 mumol/g wet weight for trimethylamines, 7.3 +/- 1.1 for creatine and 11.4 +/- 1.4 for NAA. The mean concentrations of creatine and NAA in grey matter and all of three metabolites in cerebellum were greater than those in white matter. Tumour spectra were characterized by increased trimethylamines, reduced creatine and NAA and occasionally the presence of lactate. Meningiomas were further characterized by the presence of alanine. The mean T2 and concentration of trimethylamines in tumours was significantly greater than in normal brain. Creatine and NAA concentrations were decreased in all tumours. The longer T2 of trimethylamines and presence of alanine in meningiomas indicate that important differences exist in membrane and glucose metabolism within these tumours when compared to either astrocytomas or normal brain tissue.
对39名志愿者和16名颅内肿瘤患者进行了定量质子光谱研究。在白质、灰质、小脑、星形细胞瘤和脑膜瘤中获得了T2估计值；仅在白质中测定了T1。三甲胺、肌酸和N-乙酰天门冬氨酸（NAA）在白质中的T2值分别为309±84、195±41和369±124毫秒（平均值±标准差，n = 20）。白质中三甲胺、肌酸和NAA的代谢物浓度分别为2.0±0.4μmol/g湿重、7.3±1.1和11.4±1.4。灰质中肌酸和NAA的平均浓度以及小脑中所有三种代谢物的浓度均高于白质。肿瘤光谱的特征是三甲胺增加、肌酸和NAA减少，偶尔还存在乳酸。脑膜瘤的进一步特征是存在丙氨酸。肿瘤中三甲胺的平均T2和浓度显著高于正常脑。所有肿瘤中肌酸和NAA浓度均降低。脑膜瘤中三甲胺的T2较长以及丙氨酸的存在表明，与星形细胞瘤或正常脑组织相比，这些肿瘤的膜和葡萄糖代谢存在重要差异。
