Honda M, Kamiyama Y, Kawamura K, Kawahara K, Shishido S, Nakai H, Kawamura T, Ito H
Department of Paediatric Nephrology, Tokyo Metropolitan Children's Hospital, Japan.
Pediatr Nephrol. 1995 Oct;9(5):543-8. doi: 10.1007/BF00860924.
We examined the growth, development and nutritional status over a period of 10 years of 15 young children (< 2 years old) on continuous ambulatory peritoneal dialysis (CAPD). There were 6 males and 9 females with a mean age of 12.5 months, mean weight of 6.3 kg, mean height of 66.2 cm at the start of CAPD and a mean duration of therapy of 2.6 years. Height, weight, head circumference, development quotient (DQ), blood chemistry and dietary intake were assessed over a period of 10 years. The patients' mean height standard deviation score (SDS) did not change significantly (from -2.51 to -2.74) during CAPD therapy. The mean growth velocity index (GVI) during CAPD was 76.5% and correlated positively with energy intake but not with protein intake. The mean DQ was low (67.0%) at the start of CAPD and 69.3% at the end of CAPD. DQ did not correlate with energy intake, GVI, head circumference SDS or with the weight/height ratio; however, 2 patients with low DQ (< 60%) had a low energy intakes. Although most patients had a low DQ, the IQ at 5-6 years of age was normal in all patients except 1 without cerebral disease. Our study showed minimal growth (delta SDS) and mental developmental (IQ) delays during CAPD therapy, but an adequate nutritional intake must be assured to obtain the above results.
我们对15名接受持续性非卧床腹膜透析（CAPD）的幼儿（<2岁）进行了为期10年的生长、发育及营养状况研究。其中男性6名，女性9名，开始CAPD治疗时平均年龄为12.5个月，平均体重6.3kg，平均身高66.2cm，平均治疗时长2.6年。在10年期间对身高、体重、头围、发育商（DQ）、血液生化指标及饮食摄入量进行了评估。在CAPD治疗期间，患者的平均身高标准差评分（SDS）无显著变化（从-2.51降至-2.74）。CAPD期间平均生长速度指数（GVI）为76.5%，与能量摄入量呈正相关，但与蛋白质摄入量无关。CAPD开始时平均DQ较低（67.0%），结束时为69.3%。DQ与能量摄入量、GVI、头围SDS或体重/身高比均无相关性；然而，2名DQ较低（<60%）的患者能量摄入量较低。尽管大多数患者DQ较低，但除1名无脑部疾病的患者外，所有患者5 - 6岁时的智商均正常。我们的研究表明，在CAPD治疗期间生长（SDS变化值）和智力发育（智商）延迟最小，但必须确保充足的营养摄入才能取得上述结果。
