Boullin D J, Grimes R P, Orr M W
Br J Pharmacol. 1975 Dec;55(4):555-7. doi: 10.1111/j.1476-5381.1975.tb07432.x.
The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.
研究了氟哌噻吨的α-异构体和β-异构体对5-羟色胺(5-HT)诱导的血小板聚集以及对5-HT和多巴胺摄取的影响。α-氟哌噻吨作为血小板聚集抑制剂的效力比β-异构体强185倍。相比之下,两种异构体作为5-HT和多巴胺摄取抑制剂的效力相当。这些数据表明,5-HT诱导的聚集和摄取是不同的过程。