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三氟噻吨对5-羟色胺诱导的人血小板聚集以及5-羟色胺和多巴胺摄取的作用。

The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.

作者信息

Boullin D J, Grimes R P, Orr M W

出版信息

Br J Pharmacol. 1975 Dec;55(4):555-7. doi: 10.1111/j.1476-5381.1975.tb07432.x.

DOI:10.1111/j.1476-5381.1975.tb07432.x
PMID:2360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666734/
Abstract

The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.

摘要

研究了氟哌噻吨的α-异构体和β-异构体对5-羟色胺（5-HT）诱导的血小板聚集以及对5-HT和多巴胺摄取的影响。α-氟哌噻吨作为血小板聚集抑制剂的效力比β-异构体强185倍。相比之下，两种异构体作为5-HT和多巴胺摄取抑制剂的效力相当。这些数据表明，5-HT诱导的聚集和摄取是不同的过程。

相似文献

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The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.三氟噻吨对5-羟色胺诱导的人血小板聚集以及5-羟色胺和多巴胺摄取的作用。
Br J Pharmacol. 1975 Dec;55(4):555-7. doi: 10.1111/j.1476-5381.1975.tb07432.x.
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Effects of alpha-flupenthixol on dopamine and 5-hydroxytryptamine responses of substantia nigra neurones.
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本文引用的文献

1
Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA.正常受试者以及接受左旋多巴治疗的帕金森病患者血小板对多巴胺的摄取。
Br J Pharmacol. 1970 Aug;39(4):779-88. doi: 10.1111/j.1476-5381.1970.tb09904.x.
2
On flupentixol, an antidepressant of a new chemical group.
Br J Psychiatry. 1969 Dec;115(529):1399-402. doi: 10.1192/bjp.115.529.1399.
3
The mechanism of adenosine diphosphate induced platelet aggregation: binding to platelet receptors and inhibition of binding and aggregation by prostaglandin E 1 .二磷酸腺苷诱导血小板聚集的机制：与血小板受体结合以及前列腺素E1对结合和聚集的抑制作用。
J Physiol. 1972 Mar;221(2):415-26. doi: 10.1113/jphysiol.1972.sp009758.
4
Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.5-羟色胺及几种类似物对人体血小板的相对活性及摄取情况
Br J Pharmacol. 1972 Jan;44(1):117-39. doi: 10.1111/j.1476-5381.1972.tb07244.x.
5
The comparative pharmacology of flupenthixol and some reference neuroleptics.氟哌噻吨与一些对照抗精神病药物的比较药理学
Acta Pharmacol Toxicol (Copenh). 1973;33(5):353-62. doi: 10.1111/j.1600-0773.1973.tb01537.x.
6
Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
Br J Pharmacol. 1975 Jan;53(1):121-5. doi: 10.1111/j.1476-5381.1975.tb07338.x.
7
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.