三氟噻吨对5-羟色胺诱导的人血小板聚集以及5-羟色胺和多巴胺摄取的作用。
The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.
作者信息
Boullin D J, Grimes R P, Orr M W
出版信息
Br J Pharmacol. 1975 Dec;55(4):555-7. doi: 10.1111/j.1476-5381.1975.tb07432.x.
Abstract
The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent as inhibitors of uptake of 5-HT and dopamine. The data suggest that 5-HT-induced aggregation and uptake are separate processes.
摘要
研究了氟哌噻吨的α-异构体和β-异构体对5-羟色胺（5-HT）诱导的血小板聚集以及对5-HT和多巴胺摄取的影响。α-氟哌噻吨作为血小板聚集抑制剂的效力比β-异构体强185倍。相比之下，两种异构体作为5-HT和多巴胺摄取抑制剂的效力相当。这些数据表明，5-HT诱导的聚集和摄取是不同的过程。
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