Herremans A H, Hijzen T H, Slangen J L
Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences, Faculty of Pharmacy, Utrecht University, The Netherlands.
Neuroreport. 1995 Oct 23;6(15):1963-5. doi: 10.1097/00001756-199510010-00003.
Four rats were trained on an object delayed non-matching to sample task to measure working memory (WM). On separate trials a sample object was presented to the rat, which was presented again along with another object after a 3 s delay rats were rewarded with food if they chose the novel object. In this procedure the choice objects are positioned in a fixed order (the novel object was positioned at first, followed by the sample object). When the order of placement of the choice objects was reversed performance dropped from 87% to 28% correct, showing that the rats always chose the object that was first positioned into the choice area. When the order of positioning of the choice objects was randomized during training, rats were not able to learn the task. It is suggested that performance is based on a discrimination between choice objects instead of WM.
四只大鼠接受了物体延迟非匹配样本任务训练，以测量工作记忆（WM）。在单独的试验中，向大鼠呈现一个样本物体，3秒延迟后，该样本物体与另一个物体再次呈现，如果大鼠选择了新物体，就会得到食物奖励。在这个过程中，选择物体按固定顺序摆放（新物体先摆放，然后是样本物体）。当选择物体的摆放顺序颠倒时，正确表现从87%降至28%，这表明大鼠总是选择首先放入选择区域的物体。当在训练过程中选择物体的摆放顺序随机化时，大鼠无法学会该任务。这表明表现是基于对选择物体的辨别，而非工作记忆。
