Janerich D T, Dugan J M, Standfast S J, Strite L
Br Med J. 1977 Apr 23;1(6068):1058-60. doi: 10.1136/bmj.1.6068.1058.
One-hundred and four infants with congenital heart disease were identified from their birth certificates and matched with normal controls. Their gestational histories were examined to see whether they had been exposed to exogenous sex hormones. Exposure was 8-5 times more common among the infants with malformations than among controls. A history of hormone exposure was more common among those patients with multiple malformations, and the exposed infants were also more likely to have died (and to have died earlier) than those who had not been exposed, which suggests that hormone exposure causes severe types of malformations. The commonest type of exposure was to hormone pregnancy tests, which was needless exposure. Only two of the mothers of malformed infants had inadvertently used oral contraceptives in the first trimester.
从出生证明中识别出104名患有先天性心脏病的婴儿，并与正常对照组进行匹配。检查他们的妊娠史，看是否接触过外源性性激素。畸形婴儿中激素接触的情况比对照组普遍8至5倍。激素接触史在患有多种畸形的患者中更为常见，而且接触过激素的婴儿比未接触过的婴儿更有可能死亡（且死亡时间更早），这表明激素接触会导致严重类型的畸形。最常见的接触类型是激素妊娠试验，这是不必要的接触。畸形婴儿的母亲中只有两人在孕早期无意中使用过口服避孕药。
