Chen S G, Li C C, Zhuang X X
Dept. Pharmacology, Medical College of Shantou University, Guangdong.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Aug;15(8):486-8.
The injection of aqueous extract of Angelica sinensis (AS), 50 mg/kg, 30 ml, were administered intravenously at a rate of 0.4 ml/min by an infusion pump 10 min before the left anterior descending coronary artery of rabbit was ligated, the LVP and +/- dp/dtmax of the rabbit heart injured by ischemia/reperfusion in vivo, were significantly higher than those in the control group (N.S. group, P < 0.05-0.01), and the level of malon-dialdehyde (MDA) and the activity of creatine phosphokinase (CPK) in the blood plasma were lower than those in the control group remarkably (P < 0.05-0.01). These results showed that AS exerted obvious protective effects on myocardial dysfunction and myocardial injury induced by ischemia/reperfusion.
在兔左冠状动脉前降支结扎前10分钟，用输液泵以0.4毫升/分钟的速度静脉注射50毫克/千克、30毫升的当归水提取物，兔体内缺血/再灌注损伤心脏的左心室压（LVP）和±dp/dtmax显著高于对照组（生理盐水组，P<0.05 - 0.01），血浆中丙二醛（MDA）水平和肌酸磷酸激酶（CPK）活性明显低于对照组（P<0.05 - 0.01）。这些结果表明，当归对缺血/再灌注诱导的心肌功能障碍和心肌损伤具有明显的保护作用。
