Watt S M, Gschmeissner S E, Bates P A
MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford, U.K.
Leuk Lymphoma. 1995 Apr;17(3-4):229-44. doi: 10.3109/10428199509056827.
PECAM-1, the platelet-endothelial cell adhesion molecule, is expressed on a variety of mature hemopoietic cell types (including neutrophils, monocytes and T cell subsets) and is also present on endothelia. In such cases, this glycoprotein functions as either a homotypic or heterotypic adhesion molecule contributing to cell migration, inflammatory processes and wound healing. We have recently shown that PECAM-1 is expressed on a variety of hemopoietic progenitor cell types and on stromal macrophages from human bone marrow. In this review, we discuss the possible functional significance of this molecule for both hemopoietic cell differentiation and for mature cells.
血小板内皮细胞黏附分子（PECAM-1）在多种成熟造血细胞类型（包括中性粒细胞、单核细胞和T细胞亚群）上表达，并且也存在于内皮细胞上。在这些情况下，这种糖蛋白作为同型或异型黏附分子发挥作用，有助于细胞迁移、炎症过程和伤口愈合。我们最近发现，PECAM-1在多种造血祖细胞类型以及人骨髓的基质巨噬细胞上表达。在这篇综述中，我们讨论了该分子对造血细胞分化和成熟细胞可能具有的功能意义。
