Dorson M, Quillet E, Hollebecq M G, Torhy C, Chevassus B
INRA, unité de virologie et d'immunologie moléculaires, pathologie infectieuse et immunité des poissons, Jouy-en-Josas, France.
Vet Res. 1995;26(5-6):361-8.
In 1984 a programme of selection for resistance to viral haemorrhagic septicaemia virus (VHSV) in rainbow trout was initiated. The progenies of 14 males were submitted to a VHSV waterborne challenge. The mortality ranged from 30 to 95% and the heritability of resistance was estimated to be 0.63 +/- 0.26. One male consistently provided the most resistant offspring, and the second generation was produced from sires and dams selected among these families. The mean resistance improved and several females giving birth to resistant offspring were identified (0-10% mortality while the mortality in the controls was from 70 to 90%). The meiotic gynogenetic progeny of these females also demonstrated high resistance (mortality less than 10%). The role of superficial tissues in the resistance was confirmed and there was a striking difference in the growth of VHSV in fins excised and infected in vitro. The fins from resistant fish replicated the virus poorly as compared with the fins of susceptible fish.
1984年，一项针对虹鳟抗病毒性出血性败血症病毒（VHSV）的选育计划启动。14只雄性虹鳟的后代接受了VHSV的水体感染挑战。死亡率在30%至95%之间，抗性的遗传力估计为0.63±0.26。有一只雄性虹鳟始终能产出抗性最强的后代，第二代则由从这些家族中挑选出的雄鱼和雌鱼繁育而来。平均抗性有所提高，并且鉴定出了几只产出抗性后代的雌鱼（死亡率为0 - 10%，而对照组的死亡率为70%至90%）。这些雌鱼的减数分裂雌核发育后代也表现出高抗性（死亡率低于10%）。证实了体表组织在抗性中的作用，并且在体外切除并感染的鱼鳍中，VHSV的生长存在显著差异。与易感鱼的鱼鳍相比，抗性鱼的鱼鳍对病毒的复制能力较差。
