Rettenberger G, Klett C, Zechner U, Bruch J, Just W, Vogel W, Hameister H
Institut für Nutztierwissenschaften ETH-Zürich, Switzerland.
Chromosome Res. 1995 Dec;3(8):479-86. doi: 10.1007/BF00713962.
DNA in situ hybridization with human chromosome specific DNA libraries was applied to compare the karyotypes of humans (Homo sapiens, 2n = 46) and cats (Felis catus, 2n = 38). For the autosomes alone, 30 segments of conserved synteny were revealed. The arrangement of these segments in the feline karyotype differs by only seven single chromosome breaks and one intrachromosomal inversion from their arrangement in humans. Comparison of these data with those recently obtained for pig and those available from conventional gene mapping studies in mice and cattle has allowed us to develop a model of karyotype evolution in mammals. The cat and human karyotypes, with 36 and 44 autosomes respectively, were found to be very similar to a putative ancient mammalian founder karyotype. It would appear that during evolution to the human karyotype the status quo has been conserved for at least some 100-120 million years. There has been no need to alter the well-balanced gene arrangement of the mammalian founder karyotype.
应用人类染色体特异性DNA文库进行DNA原位杂交，以比较人类（智人，2n = 46）和猫（家猫，2n = 38）的核型。仅就常染色体而言，发现了30个保守同线性区段。这些区段在猫核型中的排列与在人类核型中的排列相比，仅存在7个单染色体断裂和1次染色体内倒位的差异。将这些数据与最近获得的猪的数据以及从小鼠和牛的传统基因图谱研究中得到的数据进行比较，使我们能够建立一个哺乳动物核型进化模型。分别具有36条和44条常染色体的猫和人类核型，被发现与一种假定的古代哺乳动物原始核型非常相似。在向人类核型进化的过程中，至少在约1亿至1.2亿年的时间里，这种现状得以保留。没有必要改变哺乳动物原始核型中平衡良好的基因排列。
