Hayden M K, Matushek M G, Trenholme G M
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
Diagn Microbiol Infect Dis. 1995 Aug;22(4):349-52. doi: 10.1016/0732-8893(95)00144-1.
The in vitro activities of levofloxacin and other antibiotics against 133 clinical isolates of vancomycin-resistant and vancomycin-susceptible enterococci were evaluated. Only 14 (39%) of the vancomycin-susceptible isolates and 11 (11%) of the vancomycin-resistant isolates were susceptible to levofloxacin. Levofloxacin exhibited a marked inoculum effect for all enterococci tested. These results suggest that levofloxacin may be of limited use in the treatment of serious enterococcal infections.
对左氧氟沙星和其他抗生素针对133株耐万古霉素和万古霉素敏感肠球菌临床分离株的体外活性进行了评估。仅14株（39%）万古霉素敏感分离株和11株（11%）耐万古霉素分离株对左氧氟沙星敏感。左氧氟沙星对所有测试的肠球菌均表现出明显的接种量效应。这些结果表明左氧氟沙星在治疗严重肠球菌感染中的应用可能有限。
