Forster J, Schumacher R F
Universitäts-Kinderklinik, Freiburg, Germany.
Eur J Pediatr. 1995 Nov;154(11):901-5. doi: 10.1007/BF01957502.
During the course of a 3-year epidemic of respiratory syncytial virus (RSV) in an Neonatal Intensive Care Unit, we examined premature neonates for the clinical features of RSV infections and the risk factors predisposing towards transmission of the disease. Seventy-nine infants with a median gestational age of 31 weeks were tested in 113 episodes of clinical deterioration for the presence of RSV antigen in nasopharyngeal secretions. Forty-seven results were positive and 66 negative. Bradycardia, which is gestational-age dependent, was the main presenting clinical symptom of an RSV infection in 75% of cases. The probability of an RSV-positive result in an episode with bradycardia, hypercapnia and fever was calculated to be 0.75. The only identifiable epidemiological risk factor was the total number of symptomatic RSV-infected infants in the ward. CONCLUSION. Bradycardia may indicate the presence of an RSV infection: the appropriate tests should be carried out and infection control reinforced immediately.
在一家新生儿重症监护病房为期3年的呼吸道合胞病毒（RSV）流行期间，我们检查了早产儿RSV感染的临床特征以及疾病传播的易感风险因素。在113次临床病情恶化发作中，对79名中位胎龄为31周的婴儿进行了检测，以确定其鼻咽分泌物中是否存在RSV抗原。47例结果为阳性，66例为阴性。心动过缓与胎龄有关，是75%病例中RSV感染的主要临床症状。在伴有心动过缓、高碳酸血症和发热的发作中，RSV检测结果为阳性的概率经计算为0.75。唯一可识别的流行病学风险因素是病房中有症状的RSV感染婴儿总数。结论。心动过缓可能表明存在RSV感染：应进行适当检测并立即加强感染控制。
