Bilgihan A, Bilgihan M K, Akata R F, Aricioğlu A, Hasanreisoğlu B
Department of Biochemistry, University of Gazi, Medical Faculty, Anakara, Turkey.
Free Radic Biol Med. 1995 Dec;19(6):883-5. doi: 10.1016/0891-5849(95)00093-d.
Ocular melanin pigment has antioxidant effect against excess of dispersed light. To investigate whether it has a similar effect in ocular inflammations, we used albino and pigmented guinea pigs and measured retinal glutathione peroxidase activities and lipid peroxide levels (expressed as thiobarbituric acid reactive substances) in a model of lens induced uveitis. Although the increase in the levels of the retinal lipid peroxides were higher in the albino group (204%, p < 0.05), the decrease in the activities of glutathione peroxidase were higher in pigmented guinea pigs (26%, p < 0.005). The results of the study suggest that pigmentless animals are more sensitive to the ocular inflammations, and ocular melanin pigment may act as an endojen antioxidant in lens induced uveitis.
眼部黑色素对过量散射光具有抗氧化作用。为研究其在眼部炎症中是否具有类似作用，我们使用了白化豚鼠和有色豚鼠，并在晶状体诱导性葡萄膜炎模型中测量了视网膜谷胱甘肽过氧化物酶活性和脂质过氧化物水平（以硫代巴比妥酸反应性物质表示）。尽管白化豚鼠组视网膜脂质过氧化物水平的升高幅度更大（204%，p<0.05），但有色豚鼠谷胱甘肽过氧化物酶活性的降低幅度更大（26%，p<0.005）。研究结果表明，无色素动物对眼部炎症更敏感，眼部黑色素可能在晶状体诱导性葡萄膜炎中作为内源性抗氧化剂发挥作用。
