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The effect of EGb 761 on retinal lipid peroxidation and glutathione peroxidase level in experimental lens induced uveitis.

作者信息

Bilgihan A, Aricioğlu A, Bilgihan K, Onol M, Hasanreisoğlu B, Türközkan N

机构信息

Department of Biochemistry, Gazi University, Medical Faculty, Ankara, Turkey.

出版信息

Int Ophthalmol. 1994;18(1):21-4. doi: 10.1007/BF00919409.

DOI:10.1007/BF00919409
PMID:7960411
Abstract

An acute lens-induced necrotizing intraocular inflammation was produced in pigmented guinea pigs. Treatment of these animals by 100 mg/kg/day EGb 761 a free oxygen radical scavenger for 10 days, reduced retinal lipid peroxidation (p > 0.05) and increased the retinal glutathione peroxidase level (p > 0.05). Although not significantly, these findings suggest that EGb 761 could be combined with other antiinflammatory drugs and may be beneficial in the treatment of uveitis.

摘要

相似文献

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本文引用的文献

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Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract.白内障形成的分子机制：III. 作为脂质过氧化和白内障引发剂的氧的毒性代谢产物
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7
Role of oxygen radicals in ocular inflammation and cellular damage.氧自由基在眼部炎症和细胞损伤中的作用。
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8
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9
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.红细胞谷胱甘肽过氧化物酶的定量和定性特征研究。
J Lab Clin Med. 1967 Jul;70(1):158-69.
10
Effect of lipid peroxidation on rhodopsin regeneration.脂质过氧化对视紫红质再生的影响。
Curr Eye Res. 1985 Jan;4(1):65-71. doi: 10.3109/02713688508999969.