McCue P A, Gomella L G, Veltri R W, Marley G M, Miller M C, Lattime E C
Department of Pathology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Urol. 1996 Mar;155(3):1128-32.
The growth of human bladder transitional cell carcinoma (TCC) in scid/scid mice was examined.
Cystocopically obtained TCC biopsies were implanted in scid/scid mice, and successful xenografts were compared with original tumors for growth and genetic characteristics.
Low grade papillary tumors formed fluid-filled pseudobladders lined with malignant urothelium and papillary fronds containing fibrovascular cores recruited from the murine host. High grade xenografts grew without these secondary structures. When compared with the patient tumors, xenograft growth fractures, as measured by proliferating cell nuclear antigen, p53 expression and ploidy, were similar in each.
The scid/scid xenografts maintain phenotype and architecture. This model may be useful for studying factors determining tumor grade, angiogenesis and tissue organization.
研究人膀胱移行细胞癌（TCC）在重度联合免疫缺陷（scid/scid）小鼠体内的生长情况。
通过膀胱镜获取TCC活检组织并植入scid/scid小鼠体内，将成功的异种移植瘤与原发肿瘤的生长和遗传特征进行比较。
低级别乳头状肿瘤形成充满液体的假膀胱，内衬恶性尿路上皮，乳头状叶含有从鼠宿主募集的纤维血管核心。高级别异种移植瘤无这些二级结构生长。与患者肿瘤相比，通过增殖细胞核抗原、p53表达和倍性测量的异种移植瘤生长情况在各方面相似。
scid/scid异种移植瘤保持表型和结构。该模型可能有助于研究决定肿瘤分级、血管生成和组织组织的因素。
