Moul J W, Maygarden S J, Ware J L, Mohler J L, Maher P D, Schenkman N S, Ho C K
Department of Surgery, Walter Reed Army Medical Center, Washington, D.C., USA.
J Urol. 1996 Mar;155(3):982-5.
We determined if immunohistochemical expression of the epidermal growth factor receptor and cathepsin D in the primary tumor was of prognostic value in clinically localized prostate cancer after radical prostatectomy.
Immunohistochemical staining for epidermal growth factor receptor and cathepsin D was performed on 105 radical prostatectomy specimens from 2 academic centers. The epidermal growth factor receptor and cathepsin D expressions were graded using H scoring by an experienced pathologist blinded to other patient data, and compared with age, grade, stage, race and initial serologic (prostate specific antigen) recurrence. Univariate and multivariate statistical testing was performed.
Immunohistochemically detectable epidermal growth factor receptor and cathepsin D expression was not correlated to age, race, stage or Gleason grade. In univariate and multivariate testing epidermal growth factor receptor and cathepsin D were not prognostic markers for disease progression following radical prostatectomy.
Immunohistochemical analysis of the biomarkers cathepsin D and epidermal growth factor receptor in radical prostatectomy specimens does not predict disease recurrence. Further biological marker study is needed in clinically localized prostate cancer.
我们确定了原发性肿瘤中表皮生长因子受体和组织蛋白酶D的免疫组化表达对根治性前列腺切除术后临床局限性前列腺癌是否具有预后价值。
对来自2个学术中心的105份根治性前列腺切除术标本进行表皮生长因子受体和组织蛋白酶D的免疫组化染色。由一位对其他患者数据不知情的经验丰富的病理学家采用H评分法对表皮生长因子受体和组织蛋白酶D的表达进行分级，并与年龄、分级、分期、种族和初始血清学（前列腺特异性抗原）复发情况进行比较。进行单因素和多因素统计检验。
免疫组化可检测到的表皮生长因子受体和组织蛋白酶D表达与年龄、种族、分期或 Gleason分级无关。在单因素和多因素检验中，表皮生长因子受体和组织蛋白酶D不是根治性前列腺切除术后疾病进展的预后标志物。
对根治性前列腺切除术标本中的生物标志物组织蛋白酶D和表皮生长因子受体进行免疫组化分析不能预测疾病复发。临床局限性前列腺癌需要进一步开展生物标志物研究。
