Nakayama M, Riggs L C, Matz G J
Department of Surgery, Southern Illinois University School of Medicine, Springfield, USA.
Laryngoscope. 1996 Feb;106(2 Pt 1):162-7. doi: 10.1097/00005537-199602000-00011.
Although aminoglycoside vestibulotoxicity is well established, the question of cisplatin vestibulotoxicity is controversial. The goals of this study were 1. to determine whether cisplatin induces vestibulotoxicity as measured histologically, and 2. to compare the vestibulotoxicity between gentamicin and cisplatin. Guinea pigs' vestibular end-organ hair bundles in control, gentamicin, and cisplatin groups were compared. In the lateral cristae of the cisplatin group, hair bundles decreased 21% on the central apex portion. In the gentamicin group, a slight decrease (17%) of hair bundles on the striola from the utricular maculae was observed, as was severe damage on the entire cristae, especially on the central apex (70%). These results indicate that gentamicin and cisplatin may not influence vestibular function of the otolithic membrane. However, gentamicin may severely damage and cisplatin may slightly damage the crista ampullaris hair bundles.
尽管氨基糖苷类药物的前庭毒性已得到充分证实，但顺铂的前庭毒性问题仍存在争议。本研究的目的是：1. 通过组织学测量确定顺铂是否会诱发前庭毒性；2. 比较庆大霉素和顺铂之间的前庭毒性。比较了对照组、庆大霉素组和顺铂组豚鼠的前庭终器毛束。在顺铂组的外侧嵴中，中央顶部的毛束减少了21%。在庆大霉素组中，观察到椭圆囊斑的纹区毛束略有减少（17%），整个嵴也有严重损伤，尤其是中央顶部（70%）。这些结果表明，庆大霉素和顺铂可能不会影响耳石膜的前庭功能。然而，庆大霉素可能会严重损伤壶腹嵴毛束，而顺铂可能会轻微损伤。
