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Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs.

作者信息

Nakagawa T, Yamane H, Shibata S, Nakai Y

机构信息

Department of Otorhinolaryngology, Yodogawa Christian Hospital, Osaka, Japan.

出版信息

Eur Arch Otorhinolaryngol. 1997;254(1):9-14. doi: 10.1007/BF02630749.

DOI:10.1007/BF02630749
PMID:9115709
Abstract

To clarify mechanisms of inner ear cell death induced by aminoglycosides, we used an in situ nick-end labelling method to examine guinea pig vestibular epithelia after chronic systemic treatments with gentamicin to produce apoptosis. Such changes occurred in damaged hair cells, suggesting that this process may be crucial for subsequent repair and cell regeneration.

摘要

相似文献

1
Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs.
Eur Arch Otorhinolaryngol. 1997;254(1):9-14. doi: 10.1007/BF02630749.
2
In vivo regeneration of vestibular hair cells of guinea pig.豚鼠前庭毛细胞的体内再生
Acta Otolaryngol Suppl. 1995;520 Pt 1:174-7.
3
Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity.钙蛋白酶和半胱天冬酶抑制剂可保护前庭感觉细胞免受庆大霉素耳毒性的影响。
Acta Otolaryngol. 2003 May;123(4):459-65. doi: 10.1080/00016480310001312.
4
Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death.c-Jun氨基末端激酶通路的阻断减轻庆大霉素诱导的耳蜗和前庭毛细胞死亡。
Hear Res. 2002 Apr;166(1-2):33-43. doi: 10.1016/s0378-5955(01)00388-4.
5
Nitric oxide in guinea pig vestibular sensory cells following gentamicin exposure in vitro.
Acta Otolaryngol. 2001 Apr;121(3):346-50. doi: 10.1080/000164801300102734.
6
Cell death caused by the acute effects of aminoglycoside and zinc in the ampullary cristae of guinea pigs.氨基糖苷类药物和锌对豚鼠壶腹嵴的急性作用所导致的细胞死亡。
Eur Arch Otorhinolaryngol. 1997;254(3):153-7. doi: 10.1007/BF02471281.
7
Quantitative study of vestibulotoxicity induced by gentamicin or cisplatin in the guinea pig.庆大霉素或顺铂对豚鼠前庭毒性的定量研究。
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[Regeneration and functional restoration of vestibular hair cells in guinea pigs after gentamicin damage].[庆大霉素损伤后豚鼠前庭毛细胞的再生与功能恢复]
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1997 Jun;32(3):153-6.
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Does vestibular end-organ function recover after gentamicin-induced trauma in Guinea pigs?豚鼠庆大霉素诱导性损伤后前庭终器功能会恢复吗？
Audiol Neurootol. 2014;19(2):135-50. doi: 10.1159/000357587. Epub 2014 Feb 13.
10
Uptake of amikacin by hair cells of the guinea pig cochlea and vestibule and ototoxicity: comparison with gentamicin.豚鼠耳蜗和前庭毛细胞对阿米卡星的摄取及其耳毒性：与庆大霉素的比较。
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The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans.前庭壶腹连接部在大鼠亚慢性链霉素和人类感觉上皮应激后被破坏。
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本文引用的文献

1
Apoptosis in the normal olfactory epithelium of the adult guinea pig.成年豚鼠正常嗅上皮中的细胞凋亡。
Eur Arch Otorhinolaryngol. 1996;253(6):371-3. doi: 10.1007/BF00178295.
2
In vivo regeneration of vestibular hair cells of guinea pig.豚鼠前庭毛细胞的体内再生
Acta Otolaryngol Suppl. 1995;520 Pt 1:174-7.
3
Histological evidence for hair cell regeneration after ototoxic cell destruction with local application of gentamicin in the chinchilla crista ampullaris.在豚鼠壶腹嵴局部应用庆大霉素导致耳毒性细胞破坏后毛细胞再生的组织学证据。
通过体内 Htra2 基因编辑预防小鼠获得性感觉神经性听力损失。
Genome Biol. 2021 Mar 22;22(1):86. doi: 10.1186/s13059-021-02311-4.
4
Loss of Afferent Vestibular Input Produces Central Adaptation and Increased Gain of Vestibular Prosthetic Stimulation.前庭传入输入丧失会导致中枢适应并增加前庭假体刺激的增益。
J Assoc Res Otolaryngol. 2016 Feb;17(1):19-35. doi: 10.1007/s10162-015-0544-6. Epub 2015 Oct 5.
5
Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal.耳毒性药物停用后耳蜗内毛细胞带状突触的自发和部分修复
Mol Neurobiol. 2015 Dec;52(3):1680-1689. doi: 10.1007/s12035-014-8951-y. Epub 2014 Nov 7.
6
In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period.在耳毒性敏感期，X 连锁凋亡抑制蛋白的体内过表达可防止新霉素诱导的耳蜗顶部毛细胞丢失。
Front Cell Neurosci. 2014 Sep 15;8:248. doi: 10.3389/fncel.2014.00248. eCollection 2014.
7
Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs.庆大霉素经镫骨底板给药比经圆窗给药对豚鼠造成更大的听力损失和前庭毒性。
Hear Res. 2013 Oct;304:159-66. doi: 10.1016/j.heares.2013.07.013. Epub 2013 Jul 27.
8
Cochlear inner hair cell ribbon synapse is the primary target of ototoxic aminoglycoside stimuli.耳蜗内毛细胞带状突触是耳毒性氨基糖苷类刺激物的主要靶标。
Mol Neurobiol. 2013 Dec;48(3):647-54. doi: 10.1007/s12035-013-8454-2. Epub 2013 Apr 20.
9
Effect of different gentamicin dose on the plasticity of the ribbon synapses in cochlear inner hair cells of C57BL/6J mice.不同庆大霉素剂量对 C57BL/6J 小鼠耳蜗内毛细胞带状突触可塑性的影响。
Mol Neurobiol. 2012 Oct;46(2):487-94. doi: 10.1007/s12035-012-8312-7. Epub 2012 Aug 4.
10
Localization of gentamicin uptake in the acutely isolated inner ear of the rat.庆大霉素在急性分离的大鼠内耳中的摄取定位。
Int J Physiol Pathophysiol Pharmacol. 2011;3(2):71-87. Epub 2011 Mar 28.
Hear Res. 1995 Sep;89(1-2):194-202. doi: 10.1016/0378-5955(95)00137-7.
4
Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.成年豚鼠和人类内耳感觉上皮中的再生性增殖。
Science. 1993 Mar 12;259(5101):1619-22. doi: 10.1126/science.8456285.
5
Ultrastructural evidence for hair cell regeneration in the mammalian inner ear.哺乳动物内耳毛细胞再生的超微结构证据。
Science. 1993 Mar 12;259(5101):1616-9. doi: 10.1126/science.8456284.
6
Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain.通过大鼠脑组织学和凝胶电泳联合观察证实的全脑缺血后DNA片段化的区域变异性。
J Neurochem. 1993 Nov;61(5):1973-6. doi: 10.1111/j.1471-4159.1993.tb09843.x.
7
Inner ear hair cell regeneration in a mammal: identification of a triggering factor.哺乳动物内耳毛细胞再生：一种触发因子的鉴定
Laryngoscope. 1994 Jun;104(6 Pt 1):701-18. doi: 10.1288/00005537-199406000-00010.
8
Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver.长期喂食乙醇会增加大鼠肝脏中的细胞凋亡和细胞增殖。
J Hepatol. 1994 Apr;20(4):508-13. doi: 10.1016/s0168-8278(05)80498-2.
9
Detection of apoptosis by electron microscopy and in situ labelling in the rat olfactory pit.通过电子显微镜和原位标记法检测大鼠嗅窝中的细胞凋亡。
Neuroreport. 1994 Jul 21;5(12):1429-32. doi: 10.1097/00001756-199407000-00006.
10
Apoptosis: programmed cell death in health and disease.细胞凋亡：健康与疾病中的程序性细胞死亡。
Biosci Rep. 1994 Apr;14(2):67-81. doi: 10.1007/BF01210302.