GG167（4-胍基-2,4-二脱氧-2,3-脱氢-N-乙酰神经氨酸）是雪貂体内流感病毒的强效抑制剂。
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets.
作者信息
Ryan D M, Ticehurst J, Dempsey M H
机构信息
Glaxo Wellcome Research and Development Limited, Stevenage, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1995 Nov;39(11):2583-4. doi: 10.1128/AAC.39.11.2583.
Abstract
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a novel viral neuraminidase (sialidase) inhibitor which, following intranasal administration in ferrets, is at least 100 to 1,000 times more effective than ribavirin and amantadine against influenza A and B viruses. It retains its activity even when treatments are delayed until 24 h postinfection and has no effect on the serum antibody response to infection.
摘要
GG167（4-胍基-2,4-二脱氧-2,3-脱氢-N-乙酰神经氨酸）是一种新型的病毒神经氨酸酶（唾液酸酶）抑制剂，在雪貂经鼻给药后，对甲型和乙型流感病毒的效力比利巴韦林和金刚烷胺至少高100至1000倍。即使治疗延迟至感染后24小时，它仍保持活性，且对感染的血清抗体反应没有影响。
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Antimicrob Agents Chemother. 1993 Jul;37(7):1473-9. doi: 10.1128/AAC.37.7.1473.
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Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase).
Antimicrob Agents Chemother. 1994 Oct;38(10):2270-5. doi: 10.1128/AAC.38.10.2270.
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