Grabowska-Maślanka H, Janik A
Katedra Patofizjologii Collegium Medicum UJ w Krakowie.
Folia Med Cracov. 1994;35(1-4):39-44.
The goal of this project was to observe certain paths of lipid metabolism in the aorta under the influence of chronic cadmium poisoning. A statistically very significant concentration of cadmium was found in the aortic walls of poisoned rats. However, the concentration of cadmium was not changed in the blood serum, where only a slight tendency towards increase was observed. Among the lipid compounds traced in the blood serum, a considerable increase in triglycerides was observed. The increase in the concentration of total cholesterol in the aortic wall was slight but statistically significant. The concentration of other analyzed lipids--i.e. free fatty acids, triglycerides and phospholipids--did not change. The above observations suggest the hypothesis of the possible development of atherosclerotic changes resulting from chronic cadmium poisoning.
本项目的目标是观察慢性镉中毒影响下主动脉中脂质代谢的某些途径。在中毒大鼠的主动脉壁中发现了具有统计学显著意义的镉浓度。然而，血清中的镉浓度没有变化，仅观察到轻微的上升趋势。在血清中追踪的脂质化合物中，观察到甘油三酯有相当大的增加。主动脉壁中总胆固醇浓度的增加轻微但具有统计学意义。其他分析的脂质——即游离脂肪酸、甘油三酯和磷脂——的浓度没有变化。上述观察结果提出了慢性镉中毒可能导致动脉粥样硬化变化发展的假说。
