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[镉慢性中毒对兔心肌和主动脉中某些脂质化合物的影响]

[Influence of chronic poisoning with cadmium on some lipid compounds in heart muscle and aorta of rabbits].

作者信息

Janik A, Grabowska-Maślanka H, Wajdowicz A, Gawlik M

机构信息

Katedra Patofizjologii, Collegium Medicum, Uniwersytet Jagielloński, Kraków.

出版信息

Folia Med Cracov. 1993;34(1-4):205-9.

PMID:8175060
Abstract

The detection of the influence of chronic poisoning with cadmium on some lipid metabolism in heart muscle and aorta of rabbits was the main object of the paper. A distinct cumulation of cadmium in the heart muscle was observed. However, its excessive accumulation in the wall of the aorta was not noted. A trend toward an increase of all lipid parameters, that is triglycerides, free fatty acids, phospholipids and cholesterol, was observed in the heart muscle. On the other hand, the level of phospholipids increased very distinctly in the aorta and the level of free fatty acids decreased insignificantly, which can be a favourable factor for the development of atherosclerosis processes.

摘要

检测镉慢性中毒对兔心肌和主动脉某些脂质代谢的影响是本文的主要目的。观察到镉在心肌中有明显蓄积。然而,未发现其在主动脉壁中过度蓄积。在心肌中观察到所有脂质参数(即甘油三酯、游离脂肪酸、磷脂和胆固醇)有升高趋势。另一方面,主动脉中磷脂水平明显升高,游离脂肪酸水平略有下降,这可能是动脉粥样硬化进程发展的一个有利因素。

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