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梗阻性黄疸的术前胆道引流

Preoperative biliary drainage in obstructive jaundice.

作者信息

Kawarada Y, Higashiguchi T, Yokoi H, Vaidya P, Mizumoto R

机构信息

First Department of Surgery, Mie University School of Medicine, Japan.

出版信息

Hepatogastroenterology. 1995 Jul-Aug;42(4):300-7.

PMID:8586359
Abstract

BACKGROUND/AIM: Although the role of preoperative percutaneous transhepatic biliary drainage in obstructive jaundice has been the subject of controversy in many other countries, in Japan, almost all surgeons agree that biliary decompression should be performed prior to the surgical treatment in obstructive jaundice. This study was performed in order to determine the role of preoperative percutaneous transhepatic biliary drainage in obstructive jaundice.

PATIENTS AND METHODS

We evaluated 238 patients with preoperative obstructive jaundice, and also studied its pathophysiology in experimental animal models.

RESULTS

Both of these studies demonstrated that this procedure should be performed if the value of total bilirubin is more than 5 mg/dl, the ICG Rmax value of the future remnant liver is less than 0.4 mg/kg/min, and the duration of jaundice is more than 3 weeks. Preoperative biliary drainage improves the liver function, so that major operations can be safely performed without major complications.

CONCLUSIONS

It therefore seems preferable that patients undergo preoperative biliary decompression to reduce serum total bilirubin to below 5 mg/dl, and to improve hepatic and reticuloendothelial functions and hepatic reserve prior to any major surgical operation.

摘要

背景/目的:尽管术前经皮经肝胆道引流在梗阻性黄疸中的作用在许多其他国家一直是争议的话题,但在日本,几乎所有外科医生都认为在梗阻性黄疸的手术治疗前应进行胆道减压。进行这项研究是为了确定术前经皮经肝胆道引流在梗阻性黄疸中的作用。

患者与方法

我们评估了238例术前梗阻性黄疸患者,并在实验动物模型中研究了其病理生理学。

结果

这两项研究均表明,如果总胆红素值超过5mg/dl、未来残余肝的吲哚菁绿最大清除率(ICG Rmax)值低于0.4mg/kg/min且黄疸持续时间超过3周,就应进行该操作。术前胆道引流可改善肝功能,从而能安全地进行大手术且无重大并发症。

结论

因此,患者在进行任何大手术前进行术前胆道减压,将血清总胆红素降至5mg/dl以下,并改善肝脏和网状内皮系统功能以及肝脏储备,似乎更为可取。

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