磺胺嘧啶银（AgSD：格本乳膏）治疗耐甲氧西林金黄色葡萄球菌感染的溃疡性皮肤损伤的临床疗效

[Clinical efficacy of silver sulfadiazine (AgSD: Geben cream) for ulcerative skin lesions infected with MRSA].

作者信息

Yoshida T, Ohura T, Sugihara T, Yoshida T, Ishikawa T, Homma K, Kouraba S, Kimura C, Murazumi M

机构信息

Department of Plastic and Reconstructive Surgery, School of Medicine, Hokkaido University.

出版信息

Jpn J Antibiot. 1997 Jan;50(1):39-44.

PMID:9059912

Abstract

The clinical efficacy was evaluated on 1% silver sulfadiazine (AgSD) cream (Geben cream) for the treatment of ulcerative skin lesions infected with MRSA (methicillin-resistant Staphylococcus aureus). 1% AgSD cream was applied once a day to cutaneous ulcers such as burns or decubitus or various other ulcers, infected with MRSA, in 13 patients. MRSA was eradicated in 45.5% of 11 evaluable patients. The clinical efficacy rate of 1% AgSD cream was 72.7% in this series of treatment. No side effects were noted in any of the patients, either locally or systemically. The results of the present study have indicated that 1% AgSD cream is useful for cutaneous ulcers such as burns or decubitus, infected with MRSA.

摘要

对1%磺胺嘧啶银（AgSD）乳膏（格本乳膏）治疗耐甲氧西林金黄色葡萄球菌（MRSA）感染的溃疡性皮肤损伤的临床疗效进行了评估。13例患有MRSA感染的烧伤、褥疮或其他各种溃疡等皮肤溃疡患者，每天在溃疡处涂抹一次1% AgSD乳膏。11例可评估患者中，45.5%的患者MRSA被根除。在这一系列治疗中，1% AgSD乳膏的临床有效率为72.7%。所有患者均未出现局部或全身副作用。本研究结果表明，1% AgSD乳膏对MRSA感染的烧伤、褥疮等皮肤溃疡有效。