Smith R F, Royall G D, Coss M
George Mason University, Fairfax, VA 22030, USA.
Physiol Behav. 1995 Sep;58(3):619-23. doi: 10.1016/0031-9384(95)00104-q.
Pregnant Long-Evans hooded rats were dosed with 5, 10, 20, or 40 mg/kg/d cocaine from GD7 through GD20; pairfed/vehicle-injected, and uninjected controls were included. At birth, representative pups from each litter were killed by decapitation and serum assayed for prolactin and growth hormone via radioimmunoassay. Prolactin levels were significantly reduced on P1 in offspring which had been dosed prenatally with 20 or 40 mg/kg/d, while growth hormone levels were significantly lower than control levels in the 5 and 10 mg/kg/d animals. Pairfed/vehicle controls did not differ from uninjected controls on levels of either hormone. These endocrine changes associated with cocaine dosing may affect subsequent development of the organism.
从妊娠第7天至第20天，给怀孕的Long-Evans Hooded大鼠每日腹腔注射5、10、20或40mg/kg可卡因；设置配对喂食/注射溶剂组和未注射组作为对照。出生时，每个窝中的代表性幼崽断头处死，通过放射免疫分析法检测血清中的催乳素和生长激素。产前每日给予20或40mg/kg可卡因的子代在出生后第1天的催乳素水平显著降低，而每日给予5和10mg/kg可卡因的动物生长激素水平显著低于对照组。配对喂食/注射溶剂组在两种激素水平上与未注射组无差异。这些与可卡因给药相关的内分泌变化可能会影响生物体的后续发育。
