Baron M D, Barrett T
AFRC Institute for Animal Health, Pirbright Laboratory, Surrey, UK.
Vet Microbiol. 1995 May;44(2-4):175-85. doi: 10.1016/0378-1135(95)00010-8.
We have sequenced the nucleocapsid (N) and polymerase (L) genes of the vaccine strain of rinderpest, and the 5' and 3' terminal domains of the genome. Together with previously published data, this completes the sequence of the entire genome of rinderpest virus. The L gene is identical in length to that of measles virus, encoding a 2183 amino acid protein with a calculated molecular weight of 248,100. The L protein sequence of three morbilliviruses is highly conserved, greater than 76% of residues being identical or conserved in all sequences. The N protein was, as for other sequenced genes, essentially identical to that of the virulent parent. The viral genome is 15,881 bases in length, similar to that of measles virus and slightly longer than that of canine distemper virus. The terminal sequences of the genome and those at the gene boundaries were compared to the analogous regions of other morbilliviruses and representatives of related groups of paramyxoviruses.
我们已对牛瘟疫苗株的核衣壳（N）基因和聚合酶（L）基因，以及基因组的5'和3'末端区域进行了测序。结合先前发表的数据，这就完成了牛瘟病毒全基因组的测序。L基因的长度与麻疹病毒的L基因相同，编码一种含有2183个氨基酸的蛋白质，计算分子量为248,100。三种麻疹病毒的L蛋白序列高度保守，所有序列中超过76%的残基相同或保守。与其他已测序基因一样，N蛋白与强毒株亲本的N蛋白基本相同。病毒基因组长度为15,881个碱基，与麻疹病毒的基因组长度相似，略长于犬瘟热病毒的基因组长度。将基因组的末端序列以及基因边界处的序列与其他麻疹病毒和副粘病毒相关组代表的类似区域进行了比较。
