从贝加尔湖海豹（Phoca sibirica）中分离出的麻疹病毒的特性分析。

Characterisation of morbilliviruses isolated from Lake Baikal seals (Phoca sibirica).

作者信息

Mamaev L V, Denikina N N, Belikov S I, Volchkov V E, Visser I K, Fleming M, Kai C, Harder T C, Liess B, Osterhaus A D

机构信息

Limnological Institute, Irkutsk, Russian Federation.

出版信息

Vet Microbiol. 1995 May;44(2-4):251-9. doi: 10.1016/0378-1135(95)00018-6.

DOI:10.1016/0378-1135(95)00018-6

PMID:8588319

Abstract

Sequence analysis of the haemagglutinin protein (H) gene of the morbillivirus (PDV-2) isolated from a Siberian seal (Phoca sibirica) during the 1987/1988 epizootic in Lake Baikal revealed that it was most closely related to two recent isolates of canine distemper virus (CDV) from Germany and different from CDV vaccines currently in use in that region. The virus continued to circulate in seals in Lake Baikal after the 1987/1988 epizootic since sera collected from culled seals in the spring of 1992 were positive in morbillivirus ELISA tests, reacting most strongly with the CDV antigen.

摘要

对1987/1988年贝加尔湖地区 epizootic 期间从一只西伯利亚海豹（Phoca sibirica）分离出的麻疹病毒（PDV - 2）的血凝素蛋白（H）基因进行序列分析发现，它与德国最近分离出的两株犬瘟热病毒（CDV）关系最为密切，与该地区目前使用的CDV疫苗不同。1987/1988年 epizootic 之后，该病毒继续在贝加尔湖的海豹中传播，因为1992年春季从被扑杀海豹采集的血清在麻疹病毒ELISA检测中呈阳性，与CDV抗原反应最强。