贝加尔海豹（Phoca sibirica）种群中的犬瘟热病毒多样性。

Canine distemper virus diversity in Lake Baikal seal (Phoca sibirica) population.

机构信息

Limnological Institute SB RAS, PO Box 4199, 664033 Irkutsk, Russia.

出版信息

Vet Microbiol. 2010 Jul 29;144(1-2):192-7. doi: 10.1016/j.vetmic.2009.12.027. Epub 2010 Jan 4.

DOI:10.1016/j.vetmic.2009.12.027

PMID:20083361

Abstract

Morbillivirus epizootics in marine mammals have been found in a variety of marine mammal species throughout the world over the past 20 years. The virus epizootic which resulted in significant mortality of Siberian seals (Phoca sibirica) in Lake Baikal during 1987-1988 was caused by the canine distemper virus (CDV). In our previous papers we provided evidence that the CDV similar to strain, identified in 1988, continued to circulate in Lake Baikal seals after 1988. The aim of this study was an up to date detection of CDV in Baikal seals and an evaluation of the genetic diversity of Baikal seal CDVs in comparison with other virus isolates and strains available in the GenBank on the basis of nucleotide sequence analysis of the phosphoprotein gene fragment. The majority of CDVs recovered from 1992 till 2007 were found to be similar to the one responsible for the epizootic of Lake Baikal seals. Phylogenetic analysis revealed that more than one genotype of CDV was circulating in Lake Baikal seals after the epizootic of 1987-1988.

摘要

过去 20 年来，在世界范围内的各种海洋哺乳动物中发现了麻疹病毒的流行。1987-1988 年，贝加尔湖的西伯利亚海豹（Phoca sibirica）因犬瘟热病毒（CDV）爆发了大规模死亡。在我们之前的论文中，我们提供了证据表明，1988 年鉴定的 CDV 类似株在 1988 年后继续在贝加尔湖海豹中传播。本研究的目的是实时检测贝加尔湖海豹中的 CDV，并基于磷蛋白基因片段的核苷酸序列分析，与其他病毒分离株和在 GenBank 中可用的菌株相比，评估贝加尔海豹 CDV 的遗传多样性。从 1992 年到 2007 年，从贝加尔湖海豹中分离出的大多数 CDV 被发现与导致贝加尔湖海豹流行的病毒相似。系统发育分析表明，1987-1988 年流行后，贝加尔湖海豹中循环着不止一种基因型的 CDV。