Michaels L, Soucek S, Liang J
Department of Histopathology, UCL Medical School, London, UK.
Am J Otol. 1994 Jul;15(4):515-22.
A postmortem histopathologic investigation of temporal bones of patients with the acquired immunodeficiency syndrome (AIDS) was performed after microslicing, acid decalcification of the slices and paraffin embedding. Histopathologic changes in 49 temporal bones from 25 patients included severe otitis media in five patients (20%), low-grade otitis media in fifteen (60%), labyrinthine cryptococcosis in two, Kaposi's sarcoma deposit in the eighth nerve of one, and cytomegalovirus (CMV) inclusion-bearing cells in the inner and middle ear of six (24%). It was possible to identify the CMV genome by in situ hybridization in only two bones and expression of CMV antigen by immunohistochemistry in none, probably because of prolonged decalcification in acid. The ear is no less susceptible to AIDS-associated diseases than any other organ, and is particularly prone to CMV infection.
对获得性免疫缺陷综合征（AIDS）患者的颞骨进行了尸检组织病理学研究，研究过程包括切片、切片酸脱钙和石蜡包埋。25例患者的49块颞骨的组织病理学变化包括：5例（20%）有严重中耳炎，15例（60%）有轻度中耳炎，2例有迷路隐球菌病，1例第八神经有卡波西肉瘤沉积，6例（24%）中耳和内耳有含巨细胞病毒（CMV）包涵体的细胞。仅在两块骨中通过原位杂交鉴定出CMV基因组，免疫组化未检测到CMV抗原表达，可能是因为酸脱钙时间过长。耳部与其他任何器官一样，对艾滋病相关疾病同样易感，尤其容易发生CMV感染。
