Galanis D J, McGarvey S T, Sobal J, Bausserman L, Levinson P D
Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA.
Int J Obes Relat Metab Disord. 1995 Oct;19(10):731-8.
To examine relations between obesity and serum concentrations of lipoprotein cholesterol, apolipoproteins, triglycerides and insulin in American and Western Samoans. Associations are also described between these CHD risk factors and abdominal adiposity, and the potential mediating role of insulin in these relationships is examined.
Cross-sectional, using a sub-sample from an observational epidemiological study of cardiovascular disease risk factors among Samoans.
Obesity is estimated by the body mass index (BMI), and fat distribution by the abdomen-hip circumference ratio (AHR). All biochemical parameters were measured in the fasted stated.
The sub-sample is 178 men and 147 women who were free from hypertension, diabetes and heart disease.
In multivariate linear regression analyses in men the BMI was positively associated with levels of total cholesterol, the total-HDL cholesterol ratio, apolipoprotein B, and the log of triglyceride and insulin concentrations, and negatively associated with HDL and HDL2 cholesterol. The quadratic term for BMI was also found to be significantly predictive of all metabolic parameters in men, except for the log of serum insulin concentrations. Among the women, in contrast, BMI levels were significantly associated only with concentrations of HDL2 cholesterol, triglyceride and insulin. In men, the associations between the AHR and the metabolic parameters were similar to those described for the BMI, but showed no indication of non-linearity. Addition of the log of insulin to these models had little effect on the relations between the AHR and the lipid parameters, with the exceptions of total cholesterol and triglycerides. As with BMI, the AHR was much les predictive of metabolic parameters in women than in men, with a significant relation existing only with the log of insulin concentrations.
These cross sectional data indicate that overall and abdominal adiposity are important correlates of serum lipid parameters among Samoan men, though the associations with BMI are attenuated at higher levels. Neither anthropometric indicator has much relation with these CHD risk factors among the women, perhaps due to extremely high levels of obesity in this group.
研究美国人和西萨摩亚人肥胖与血清脂蛋白胆固醇、载脂蛋白、甘油三酯及胰岛素浓度之间的关系。还描述了这些冠心病危险因素与腹部肥胖之间的关联，并探讨了胰岛素在这些关系中的潜在中介作用。
横断面研究，使用来自萨摩亚人心血管疾病危险因素观察性流行病学研究的一个子样本。
通过体重指数（BMI）评估肥胖，通过腹臀围比（AHR）评估脂肪分布。所有生化参数均在空腹状态下测量。
该子样本包括178名男性和147名女性，他们均无高血压、糖尿病和心脏病。
在男性的多变量线性回归分析中，BMI与总胆固醇水平、总胆固醇与高密度脂蛋白胆固醇比值、载脂蛋白B以及甘油三酯和胰岛素浓度的对数呈正相关，与高密度脂蛋白和高密度脂蛋白2胆固醇呈负相关。还发现BMI的二次项对男性所有代谢参数均有显著预测作用，但血清胰岛素浓度的对数除外。相比之下，在女性中，BMI水平仅与高密度脂蛋白2胆固醇、甘油三酯和胰岛素浓度显著相关。在男性中，AHR与代谢参数之间的关联与BMI所描述的相似，但未显示出非线性迹象。在这些模型中加入胰岛素的对数对AHR与脂质参数之间的关系影响不大，但总胆固醇和甘油三酯除外。与BMI一样，AHR对女性代谢参数的预测能力远低于男性，仅与胰岛素浓度的对数存在显著关系。
这些横断面数据表明，总体肥胖和腹部肥胖是萨摩亚男性血清脂质参数的重要相关因素，尽管在较高水平时与BMI的关联会减弱。这两个人体测量指标与女性的这些冠心病危险因素关系不大，可能是因为该组女性肥胖程度极高。
