人源脑膜瘤细胞对麻疹病毒易感性的体外研究。
An in vitro study of the susceptibility of cells from a meningioma of human origin for measles virus.
作者信息
Fleury H, Forsey T, Du Pasquier P
出版信息
J Neuropathol Exp Neurol. 1977 May;36(3):567-9. doi: 10.1097/00005072-197705000-00013.
Abstract
A cell culture from a meningioma of human origin was found permissive for the Edmonston strain of measles virus. Virus was isolated from the supernatant of infected cell sheet as soon as 48 hr post-inoculation. Cytopathic effect, observed by light microscopy, exhibited syncitia plus intracytoplasmic and intranuclear inclusions. Electron microscopy enabled viral nucleocapsids to be observed first in the cytoplasm and secondly within the nucleus of infected cells.
摘要
发现源自人类的脑膜瘤细胞培养物对麻疹病毒埃德蒙斯顿株敏感。接种后48小时，病毒就从感染细胞单层的上清液中分离出来。通过光学显微镜观察到的细胞病变效应表现为多核巨细胞以及胞浆内和核内包涵体。电子显微镜观察发现，病毒核衣壳首先出现在被感染细胞的细胞质中，其次出现在细胞核中。
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