Fletcher A
Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK.
Curr Opin Nephrol Hypertens. 1995 Nov;4(6):538-42. doi: 10.1097/00041552-199511000-00015.
After an explosion of interest at the beginning of the 1990s in measuring quality of life in hypertensive patients, the past few years have seen relatively few studies in this area. This is partly because when new drugs were compared, in general, no clear advantage was observed for any particular drug or class of antihypertensive. More recently the emphasis on choosing antihypertensive treatments that have been shown to be effective in reducing cardiovascular morbidity and mortality, as well as constraints on resources, have focused attention on older drugs such as diuretics. Only a few trials have measured quality of life on a diuretic, but the largest and most powerful of these found no evidence that diuretics impair quality of life.
20世纪90年代初，人们对测量高血压患者的生活质量兴趣激增，但在过去几年里，该领域的研究相对较少。部分原因是，在比较新药时，一般而言，未观察到任何特定药物或抗高血压药物类别具有明显优势。最近，由于强调选择已被证明能有效降低心血管发病率和死亡率的抗高血压治疗方法，以及资源限制，人们的注意力集中在了利尿剂等老药上。只有少数试验测量了使用利尿剂时的生活质量，但其中规模最大、效力最强的试验没有发现证据表明利尿剂会损害生活质量。
