Bremner A Douglas
Rutherglen Health Centre, 130 Stonelaw Road, Glasgow G73 2PQ, Scotland.
Cardiovasc Drugs Ther. 2002 Jul;16(4):353-64. doi: 10.1023/a:1021790112182.
Hypertension is one of the major killers in the modern world and one of the great ironies of the disease is that it has little or no immediate effect on affected individuals' quality of life (QOL). This makes treatment very difficult, as most medications will affect QOL negatively, either through side effects or through the change in life-style associated with chronic drug regimens. This review describes some of the conceptual background for QOL measurements and looks at the effects on QOL of different antihypertensive treatments available today. The latest addition to the range of antihypertensive drugs, angiotensin II-receptor blockers, may be a significant step forward in treatment, as their ease of dosing and excellent tolerability minimise negative effects on patients while their possible benefits on factors such as sexual function may even improve QOL in hypertensive patients.
高血压是现代社会的主要杀手之一，而该病极具讽刺意味的一点是，它对患者的生活质量几乎没有直接影响。这使得治疗变得非常困难，因为大多数药物都会对生活质量产生负面影响，要么是通过副作用，要么是由于与长期药物治疗方案相关的生活方式改变。这篇综述描述了生活质量测量的一些概念背景，并探讨了当今不同抗高血压治疗方法对生活质量的影响。抗高血压药物系列中的最新成员——血管紧张素II受体阻滞剂，可能是治疗方面向前迈出的重要一步，因为其给药简便且耐受性良好，将对患者的负面影响降至最低，而它们在性功能等因素方面可能带来的益处甚至可能改善高血压患者的生活质量。
