Liang N, White D J, Cox E, Busemeyer B A
The Procter and Gamble Company, Sharon Woods Technical Center, Cincinnati, Ohio, USA.
J Clin Dent. 1995;6 Spec No:80-3.
A Plaque Glycolysis and Regrowth Method (PGRM) has been used to evaluate the in vivo antimicrobial activity of a new stabilized stannous fluoride dentifrice in comparison to a control dentifrice (Regular Crest, containing NaF) and a second commercial dentifrice containing SnF2. In the method, plaque collected from subjects prior to toothbrushing served as control for subsequent plaque samples collected following toothbrushing with assigned formulations. Inhibition of plaque metabolic activity was determined by the comparative acidogenicity of normalized plaque samples as contrasted with control plaques incubated similarly. Results from a sixteen-person cross-over study demonstrated that the improved stabilized stannous fluoride dentifrice significantly reduced plaque metabolism of sucrose in comparison to both placebo and commercial SnF2 dentifrice formulations following a single toothbrushing with 2.5 grams of dentifrice for over 90 minutes following treatment. These results support the strong antimicrobial activity of the stabilized stannous fluoride dentifrice, currently marketed as Crest Gum Care, in inhibiting plaque metabolism/acid production following in vivo toothbrushing.
已采用菌斑糖酵解与再生长法（PGRM）来评估一种新型稳定化氟化亚锡牙膏与对照牙膏（含氟化钠的佳洁士常规牙膏）以及另一种含氟化亚锡的市售牙膏相比的体内抗菌活性。在该方法中，刷牙前从受试者收集的菌斑用作后续用指定配方刷牙后收集的菌斑样本的对照。通过将标准化菌斑样本与同样孵育的对照菌斑的比较产酸性来确定菌斑代谢活性的抑制情况。一项16人交叉研究的结果表明，在用2.5克牙膏刷牙单次超过90分钟后，改良的稳定化氟化亚锡牙膏与安慰剂和市售含氟化亚锡牙膏配方相比，显著降低了蔗糖的菌斑代谢。这些结果支持了目前作为佳洁士牙龈护理牙膏销售的稳定化氟化亚锡牙膏在体内刷牙后抑制菌斑代谢/产酸方面具有强大的抗菌活性。
